Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Carbon disulfide – monoxide – or dioxide
Patent
1986-12-17
1990-05-29
Rosen, Sam
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Carbon disulfide, monoxide, or dioxide
514546, 514557, 514562, A61K 3300, A61K 3122
Patent
active
049294490
ABSTRACT:
Methods are provided for preparing just before administration unit doses of therapeutic solutions which contain redox active unstable and/or diffusable metabolites such as ketoacid, a sulfhydryl-containing amino acid, or carbon dioxide. The method involves preparing and storing an aqueous solution of stable components which may or may not contain carbon dioxide. A dry powder comprised of unstable components is also prepared and stored separately. These separate component compositions are packaged in, for example, individual chambers of a common sealed container which is so constructed as to permit the opening, by externally applied manual means or the like, of a passageway between such chambers at the time when usage is contemplated. Thus, a fresh solution in desired full dosage form is preparable just before administration. Improved container structures for practice of this method are also provided.
REFERENCES:
patent: 3676553 (1972-07-01), Reynolds
patent: 3993751 (1976-11-01), Zinke
patent: 4270533 (1981-06-01), Andreas
patent: 4308255 (1981-12-01), Raj et al.
patent: 4507114 (1985-03-01), Bohman et al.
The Merck Index--Ninth edit. (1976), pp. 364 & 1041.
Chemical Abstracts--11th collective--Chemical Substances Index (1982-1986), vol. 96-105, pp. 22327cs, 22328cs and 54520cs.
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