Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Patent
1994-05-02
1995-10-31
Housel, James C.
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
422101, 422103, 206509, 383 32, 383 37, 494 38, 494 36, 494 31, 604 4, B01L 300
Patent
active
054627168
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The invention relates to a container for receiving and separating a fluid, preferably blood plasma, into its ingredients, where said container comprises two sealingly coupled sections.
BACKGROUND ART
It is known inter alia from U.S. Pat. No. 4,714,457 to utilize the plasma fraction in blood for the preparation of so-called tissue glue. According to the publication the coagulation factors, such as fibrinogen, fibronectin, factor VIII, and factor XIII are precipitated from the plasma fraction. These coagulation factors are precipitated for instance by cryoprecipitation or by means of a precipitation-promoting agent such as ethanol. The precipitated precipitate includes mainly fibrinogen and is used as tissue glue, such as in connection with operation wounds, by the addition of a suitable enzyme, such as thrombin. Like in nature, the fibrinogen and thrombin form together fibrin, which is an insoluble network of fibre-like material constituting a kind of tissue glue interconnecting the wound surfaces during a healing process. On account of the latter effect, a concentrate of coagulation factors containing mainly fibrinogen turned out to possess a favourable effect on the healing process after an operation. For short, the concentrate of coagulation factors is below referred to as fibrinogen, as said fibrinogen is the main ingredient thereof.
Several methods are today used for separating plasma from blood. The separating process can be performed by means of filters or centrifuging techniques or by way of combinations thereof. The methods are usually known as "plasmapheresis". The methods have been developed because it is often sufficient to give the patients a plasma transfusion, whereby it is unnecessary also to remove slowly regenerating blood cells from the donor.
The precipitation of fibrinogen from plasma has previously been performed in closed bag systems. The precipitation into such bags (blood bags) necessitated production of particular means for securing the bags in a for centrifugal bowl, in which the centrifuging is to be performed. In addition, it is difficult to separate the fibrinogen from the plasma in a reliable manner. The flexibility of the blood bags often results in the viscous fibrinogen loosening from the bag and mixing with the remaining plasma in the bag, whereby the concentration is substantially reduced. The latter problems have had the effect that these methods are not used by way of routine today.
DESCRIPTION OF THE INVENTION
The container according to the present invention is characterised in that at least one container section and the adjacent portion of the other container section are made substantially of solid material, that the two container sections can be separated, whereby the sections remain sealingly connected during the separating movement away from one another, that the container sections comprise their respective chamber for receiving their respective fluid ingredient, that the chambers are interconnected through a connecting channel defined by mutually abutting portions of each container section, that a valve seat is shaped at each end of the connecting channel for each valve member for a sealing closing of the chambers in the separated state of the container sections, that the valve members comprise mutually abutting projections ensuring a distance between the valve members exceeding the distance between the associated valve seats in the coupled state of the container sections, but being smaller than the distance between the associated valve seats in a position during the separating movement of the container sections, and that retaining means are provided for ensuring that the valve members do not engage the valve seats in the coupled state of the container sections.
The resulting container is well-suited for use during the precipitation of fibrinogen from plasma. In addition, the container allows a sterile storing of the two separated fractions in their respective separate container section. In this manner, the fibrinogen can be stored separatel
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Freed Rachel Heather
Housel James C.
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