Surgery – Container for blood or body treating material – or means used...
Patent
1995-05-25
1998-06-30
Clarke, Robert A.
Surgery
Container for blood or body treating material, or means used...
604415, 222 92, A61B 1900
Patent
active
057726515
DESCRIPTION:
BRIEF SUMMARY
This application claims the benefit of international application PCT/EP95/00006 filed Jan. 3, 1995.
FIELD OF THE INVENTION
This invention relates to a container containing degassed aqueous compositions for the oral air-free administration of the same.
DESCRIPTION OF THE PRIOR ART
Examination of the gastro-intestinal tract is often made difficult by the presence of gases which prevent the homogeneous distribution of the contrastographic compositions in the interior of the digestive tract. This is particularly true when ultrasonic echography of the stomach is to be performed.
Large gas volumes act as a reflecting surface for the ultrasonic waves thus darkening the nearby walls. Gas bubbles act similarly, reducing the view of the walls of stomach, duodenum and closely located structures. The use of water has been proposed to replace the gases in the stomach in order to improve the echographic view of the stomach and the other closely located organs, such as the pancreas (Crade M. et al., Am. J. Radiol. 131, 348, 1978; Fleischer et al., Am. J. Radiol. 136, 887, 1981).
For the same purpose, water containing D-sorbitol has been proposed (Hiroka et al., J. Clin. Ultrasound 17, 585, 1989). In this case, water has been previously heated to become gas-free.
WO 91/18612, published on Dec. 12, 1991, proposes the use of aqueous solutions containing biocompatible polymers which can be mixed with a compound containing silica. Unfortunately the results could not be fully reproduced since the liquid ingestion from an open container, such as a glass also brings about the ingestion of air. The quantity of ingested air varies from one individual to another. The ingested air can partly destroy the effect of enhanced echographic transparency which derives from water administration. In addition, tap water and the water left in an open container become saturated with air. Water is heated in the stomach, causing the development of air which produces bubbles. These bubbles can mar some of the positive effects on the echographic images generated by water ingestion.
SUMMARY OF THE INVENTION
This invention overcomes the above mentioned drawbacks, by supplying packages ready to be used comprising an air-tight, collapsible container, equipped with an erogating beak sealed with a detachable cap and containing a degassed aqueous diagnostic solution or suspension.
BRIEF DESCRIPTION OF THE DRAWINGS
In the drawings:
FIG. 1 is a perspective elevational view of a container according to the present invention; and
FIG. 2 is a partial cross sectional view of the container of FIG. 1 taken along the line 2--2 of FIG. 1.
This invention is also useful for packaging air sensitive diagnostic contrast media, such as for instance, solutions containing salts and/or oxidizable paramagnetic metal ion complexes, in particular Mn.sup.2+, Fe.sup.2+, Co.sup.2+, Eu.sup.2+ and V.sup.3+.
Moreover the invention is also applicable to the packaging of diagnostic formulations for the examination of the digestive tract by using X-ray and MRI techniques. These compositions for example may be solutions or suspensions of iodinated compounds, paramagnetic chelate complexes, ferromagnetic and or superparamagnetic metal derivatives or opacifying compounds such as for instance, BaSO.sub.4. Obviously these compositions may also be formulated with the addition of suitable additives and excipients, such as viscosity enhancers, sweeteners and so on usually employed for the formulation of gastro-intestinal preparations.
The packages of this invention allow the administration of degassed diagnostic compositions without the simultaneous ingestion of air since the patient drinks from the container which is squeezed directly into the oral cavity, avoiding contact between the latter and the environment air.
Turning to the drawings, in FIG. 1 there is shown a container 10 is filled with the solution or suspension. The container may be made of any material but preferably of a material compatible with heat sterilization conditions, the sterilization preferably being carried by
REFERENCES:
patent: 4516977 (1985-05-01), Herbert
patent: 4899911 (1990-02-01), Rohde et al.
patent: 5129894 (1992-07-01), Sommermeyer et al.
Canepa Valtero
De Haen Christoph
Clarke Robert A.
Dibra S.p.A.
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