Optics: measuring and testing – Sample – specimen – or standard holder or support – Fluid containers
Reexamination Certificate
2006-06-20
2006-06-20
Lauchman, Layla G. (Department: 2877)
Optics: measuring and testing
Sample, specimen, or standard holder or support
Fluid containers
C356S436000
Reexamination Certificate
active
07064823
ABSTRACT:
The present invention is a flow cytometry-based hematology system useful in the analysis of biological samples, particularly whole blood or blood-derived samples. The system is capable of determining at least a complete blood count (CBC), a five-part white blood cell differential, and a reticulocyte count from a whole blood sample. The system preferably uses a laser diode that emits a thin beam to illuminate cells in a flow cell and a lensless optical detection system to measure one or more of axial light loss, low-angle forward scattered light, high-angle forward scattered light, right angle scattered light, and time-of-flight measurements produced by the cells. The lensless optical detection system contains no optical components, other than photoreactive elements, and does not include any moving parts. Finally, the system uses a unique system of consumable reagent tubes that act as reaction chambers, mixing chambers, and waste chambers for the blood sample analyses. The consumable tubes incorporate reference particles, which act as internal standards to ensure that the dilutions made during processing of the samples have been carried out correctly, and to ensure that the instrument is working properly. The present invention also relates to methods for using the system.
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Coleman Michelle L.
Crews Harold R.
Hansen W. Peter
Roche John W.
Carter DeLuca Farrell & Schmidt LLP
IDEXX Laboratories, Inc.
Lauchman Layla G.
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