Constructs for delivery of therapeutic agents to neuronal cells

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S402000

Reexamination Certificate

active

07368532

ABSTRACT:
A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a HNdomain of a clostridial toxin and is not a fragment or derivative of a HNdomain of a clostridial toxin.

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