Constructs and methods for expression of recombinant HCV...

Details Constructs and methods for expression of recombinant HCV... Constructs and methods for expression of recombinant HCV...

2008-01-01

2008-01-01

Lucas, Zachariah (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023400, C536S023500, C435S069100, C435S069300, C435S069700, C435S069800, C435S070100, C435S071100, C435S320100, C424S184100, C424S185100, C424S189100, C424S192100

Reexamination Certificate

active

10128587

ABSTRACT:
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian lysozyme signal peptide or a functional equivalent thereof joined to a HCV envelope protein or a part thereof. Said avian lysozyme signal peptide is efficiently removed when the protein comprising said avian lysozyme signal peptide joined to a HCV envelope protein or a part thereof is expressed in a eukaryotic cell. Suitable eukaryotic cells include yeast cells such asSaccharomycesorHansenulacells.

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