Construction of high efficiency retroviral vector for gene...

Details Construction of high efficiency retroviral vector for gene... Construction of high efficiency retroviral vector for gene...

2005-01-04

2005-01-04

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Vector, per se

C435S456000

Reexamination Certificate

active

06838280

ABSTRACT:
The present invention provides a retroviral vector containing an iduronate-2-sulfatase (IDS) gene but without selective marker gene, constructed on, as a backbone, a minimum sized MLV-based retroviral vector which does not contain any viral coding sequences but can still produce a high viral titer and drive a high level of gene expression.

REFERENCES:
Romano et al. Latest developments in gene transfer technology: Achievements, perspectives, and controversies over therapeutic applications. Stem cells 18:19-39, 2000.*
McIvor, R.S. Gene therapy of genetic diseases and cancer. Pediatr. Transplantation. vol. 3, suppl. 1, pp. 116-121, 1999.*
Dang et al. Gene therapy and transiational cancer research. Clin. Cancer Res. 5:471-474, 1999.*
Kim et al. Construction of retroviral vectors with improved safety, gene expression, and versatility. J. Virol. 72:994-1004, 1998.

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