Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-25
2008-10-28
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S284100
Reexamination Certificate
active
07442712
ABSTRACT:
A compound represented by the structural formulaand pharmaceutically acceptable salts and solvents thereof is disclosed, wherein:the single-dashed linebetween the ring carbons to which R10and R34are attached represents either a single bond or a double bond;the double-dashed linebetween X and the carbon to which Y is attached represents either a single bond or an absent bond;X is —O— or —NR6— when the double-dashed line represents a single bond; X is H, —OH or —NHR20when the double-dashed line represents an absent bond;and other parameters are as defined herein.Also disclosed are pharmaceutical compositions and combinations containing said compounds and their uses as thrombin receptor antagonists and binders to cannabinoid receptors.
REFERENCES:
patent: 6063847 (2000-05-01), Chackalamannil et al.
patent: 6326380 (2001-12-01), Chackalamannil et al.
patent: 6645987 (2003-11-01), Chackalamannil et al.
patent: 6894065 (2005-05-01), Chackalamannil et al.
patent: 7037920 (2006-05-01), Chackalamannil et al.
patent: 7304078 (2007-12-01), Chackalamannil et al.
patent: 2004/0152736 (2004-08-01), Chackalamannil et al.
patent: WO 1994/03479 (1994-02-01), None
Berge, Stephen M:, et al., “Pharmacuetical Salts”, Journal of Pharmaceutical Sciences, 1977, pp. 1-19; vol. 66, issue 1.
Bernatowicz, Michael S., et al., “Development of Potent Thrombin Receptor Antagonist Peptides”, J. Med. Chem., 1996, pp. 4879-4887, vol. 39, issue 25.
Chackalamannil, Samuel., et al., “A Highly Efficient Total Synthesis of (+)− Himbacine”, J. Am. Chem. Soc., (1996), pp. 9812-9813, vol. 118, issue 40.
Pertwee, Roger G., “Pharmacology of Cannabinoid Receptor Ligands”, Current Medicinal Chemistry, 1999, pp. 635-664, vol. 6, issue 8.
International Search Report for International Application No. PCT/US2005/018372, mailed Oct. 26, 2005 (4 pages) for CV06197.
Chackalamannil Samuel
Chelliah Mariappan V.
Chintala Madhu
Clasby Martin C.
Graziano Michael P.
Reinhardt Gerard E.
Schering Corporation
Shiao Rei-tsang
LandOfFree
Constrained himbacine analogs as thrombin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Constrained himbacine analogs as thrombin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Constrained himbacine analogs as thrombin receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4007205