Constitutive expression of non-infectious HIV-like particles

Details Constitutive expression of non-infectious HIV-like particles Constitutive expression of non-infectious HIV-like particles

1997-12-16

2000-09-19

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4241881, 435236, 4353201, 435455, 536 2372, C12P 2102, C12N 1549, C07K 14155, A61K 3921

Patent

active

061210218

ABSTRACT:
Non-infectious, non-replicating immunogenic HIV-like particles are produced by stable longn-term constitutive expression in mammalian cells by eliminating elements toxic to the mammalian cells. An expression vector contains a nucleic acid molecule comprising a modified HIV genome devoid of long terminal repeats and wherein Tat and vpr sequences are functionally disabled and a constitutive promoter operatively connected to the modified HIV genome for constitutive expression of the modified genome to produce the HIV-like particles.

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