Constitutive activator of retinoid acid response (car) receptor

Details Constitutive activator of retinoid acid response (car) receptor Constitutive activator of retinoid acid response (car) receptor

1995-06-05

1997-11-11

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 234, 435 691, 435 697, C07K 14435, C12N 1562, C12N 1500, C12P 2100

Patent

active

056865740

ABSTRACT:
Purified DNA encoding a Constitutive Activator of Retinoid acid response (CAR) receptors and the recombinant proteins expressed from such DNA are disclosed. The recombinant receptor polypeptides are members of the nuclear hormone receptor super family and are used to identify CAR ligands and CAR receptor binding sites and are also used to produce therapeutics. Antibodies specific for CAR receptor polypeptides are also disclosed.

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Gebert et al., "High Frequency of Retinoic Acid Receptor .beta. Abnormalitites in Human Lung Cancer", Oncogene 6:1859-1868, 1991.
Kumar et al., "Functional Domains of the Human Estrogen Receptor", Cell 51:941-951, 1987.

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