Constant release rate solid oral dosage formulations of veropami

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 22, 424 35, A61K 922, A61K 926

Patent

active

044617593

ABSTRACT:
A constant order release rate solid oral dosage formulation of verapamil or a pharmaceutically acceptable salt thereof, said formulation comprising: a therapeutically effective amount of verapamil; from about 0.5 to 6.0 weight percent of an acid-retardant or hydrophobic cellulose derivative; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil: from about 1 to 20 weight percent of an acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 3.0 percent of a lubricant.

REFERENCES:
patent: 3577514 (1971-05-01), Robinson
Gibson et al., CA.97 #133454a(1982).
Juslin et al., CA.96 #40847v(1982).
Khanna et al., CA.94 #127301v(1981).
Jayaswal et al., CA.93 #155800e(1980).
Chasseaud et al., CA.85 #68210d(1976).
Ekenved et al., CA.76 #1037562(1972).

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