Constant release rate solid oral dosage formulations of quinidin

Details Constant release rate solid oral dosage formulations of quinidin Constant release rate solid oral dosage formulations of quinidin

1984-02-16

1985-06-04

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 22, A61K 922, A61K 926

Patent

active

045214018

ABSTRACT:
A constant order release rate solid oral dosage formulation of quinidine or a pharmaceutically acceptable salt thereof, said formulation comprising: a therapeutically effective amount of quinidine or a pharmaceutically acceptable salt; from about 0.5 to 6.0 weight percent of an acid-retardant or hydrophobic cellulose derivative; from about 2.5 to 35 weight percent of a hydrogenated vegetable oil: from about 1 to 20 weight percent of an acrylic acid polymer; from about 0.5 to 4.0 weight percent of fumed silicon dioxide and from about 0.4 to 3.0 percent of a lubricant.

REFERENCES:
patent: 3577514 (1971-05-01), Robinson
Gibson et al., C.A. 97, #133454A, (1982).
Juslin et al., C.A. 96, #40847v, (1982).
Khann et al., C.A. 94, #127301v, (1981).
Jayaswal et al., C.A. 93, #155800e, (1980).
Chasseaud et al., C.A. 85, #68210d, (1976).
Ekenved et al., C.A. 76, #1037562, (1972).
Mahon et al., C.A. 85: 51668m, (1976).
Sawyer et al., C.A. 98: 78054p, (1983).

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