Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1990-01-30
1996-07-30
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 857, 435 6951, C07K 1456
Patent
active
055412939
ABSTRACT:
Disclosed are analogs of human leukocyte interferon which predominantly include those amino acid residues which are common to all naturally-occurring human leukocyte interferon subtype amino acid sequences and which include, at one or more of those positions where there is no amino acid common to all subtypes, an amino acid which predominantly occurs at that position and in no event include any amino acid residue which is not extant in that position in at least one naturally-occurring subtype.
REFERENCES:
patent: 4695623 (1987-09-01), Stabinsky
Goeddel et al. Nature 290: 20-26 (1981).
Waterman, Nucleic Acids Res 14(22):9095-9102 (1986).
Amgen Inc.
Fitzgerald David L.
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