Consensus dengue virus envelope protein domain III...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C435S005000, C422S430000

Reexamination Certificate

active

07981431

ABSTRACT:
A consensus peptide sequence designed for domain III of the envelope proteins of four serotypes of dengue virus and used in a vaccine against multiple serotypes of dengue virus is disclosed. The vaccine is able to elicit cross-neutralization antibody responses against multiple serotypes of dengue virus.

REFERENCES:
Yauch, L. E., and S. Shresta, 2008, Mouse models of dengue virus infection and disease, Antiviral Res. 80:87-93.
Malavige, G. N., et al., 2004, Dengue viral infections, Postgraduate Medical J., 80:588-601.
Stephenson, J. R., 2005, Understanding dengue pathogenesis: implications for vaccine design, Bull. World Health Org. 83:308-314.
Whiltehead, S. S., et al., 2007, Prospects for a dengue virus vaccine, Nat. Rev. Microbiol. 5:S18-S28.

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