Conotoxin peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S012200, C530S857000, C530S327000, C530S324000

Reexamination Certificate

active

07368432

ABSTRACT:
The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. These conotoxin peptides have analgesic activity and are thus useful for treating or preventing pain.

REFERENCES:
patent: 5885797 (1999-03-01), Chen et al.
patent: 6767896 (2004-07-01), McIntosh et al.
patent: 2005/0214213 (2005-09-01), Olivera et al.
patent: PCT 0020444 (2000-04-01), None
Merriam-Webster Online Dictionary definition for “derivative,” No. 4, http://www.m-w.com/dictionary/derivative, printed on May 31, 2007.
Result 10, Geneseq database search, alignment of instant SEQ ID No. 14 with SEQ ID No. 9 of Lewis et al., WO 00/20444 A1, search performed Mar. 26, 2007.
McIntosh, J.M. (1999) “Conus Peptides as Probes for Ion Channels”, Methods in Enzymology, vol. 294: 605-624.
McIntosh, J.M. (1999) “Conus Peptides Targeted to Specific Nicontinic Acetylcholine Receptor Subtypes”, Annual Rev. Biochemistry, vol. 68:59-88.
McIntosh, J.M. et al. (2000) “Isolation and Characterization of a novel conus peptide with apparent antinociceptive activity”, Journal of Biol. Chemistry, Jul. 2000, pp. 1-31 w/ 6 pg appendix.
Olivera, B.M. et al. (1985). “Peptide Neurotoxins from Fish-Hunting Cone Snails,” Science 230:1338-1343.
Olivera, B.M. et al. (1990). “Diversity ofConusNeuropeptides,” Science 249:257-263.

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