Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 24 amino acid residues in defined sequence
Patent
1998-06-26
1999-10-19
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
24 amino acid residues in defined sequence
514 13, A61K 3800
Patent
active
059690968
ABSTRACT:
Substantially pure conotoxin peptides are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular skeletal nAChRs to the exclusion of neuronal nAChRs. The peptides are of such length that they can be made by chemical synthesis, and the preferred peptides have formula: H-His-4Hyp-4Hyp-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-4Hyp-Gly-Cys-Ser-S er-Ala-Ser-Cys-Cys-Gln-Xaa.sub.24 -NH.sub.2 wherein Xaa.sub.24 is Arg or Gly.
REFERENCES:
patent: 5432155 (1995-07-01), Olivera et al.
patent: 5595972 (1997-01-01), Olivera et al.
patent: 5633347 (1997-05-01), Olivera et al.
patent: 5700778 (1997-12-01), Olivera et al.
Shon, et al., "A Non-competitive Inhibitor of the Nicotinic Acetlcholine Receptor fron Conus purpurascensVenom" Biochemistry 1997, 36, 9581.
Shon, et al., "Three-Dimensional Solution Structure of .alpha.-Conotoxin MII, an .alpha..sub.3 .beta..sub.2 Neuronal Nicotinic Acetylcholine Receptor-Targeted Ligand", Reprinted from Biochemistry, vol. 36(50):15693-15700 (1997).
Advance ACS Abstract, Jul. 1, 1997, K. Shoen, et al., "Society for Neuroscience", 27th Annual Meeting, 1997.
Shon, et al., "A Noncompetitive Peptide Inhibitor of the Nicotinic Acetylcholine Receptor from Conus purpurascens Venom", Biochemistry, 36:9581-9587, 1997.
Dykert John
Gray William R.
Hillyard David R.
Olivera Baldomero M.
Rivier Jean E. F.
Jameison Fabian A.
The Salk Institute for Biological Studies
Tsang Cecilia J.
University of Utah Research Foundation
LandOfFree
Conotoxin peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Conotoxin peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conotoxin peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2056769