Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1996-03-29
1998-04-14
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
514 12, 514 21, A61K 3817, C07K 14435
Patent
active
057392765
ABSTRACT:
The present invention is directed to .delta.-conotoxin PVIA having the formula Glu-Ala-Cys-Tyr-Ala-Xaa.sub.1 -Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa.sub.2 -Gly-Leu-Cys-Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (Xaa.sub.1 or Xaa.sub.2 is Pro or 4-trans-hydroxyproline) (SEQ ID NO:7). The C-terminus may be free or amidated. This latter conotoxin is vertebrate-specific which targets voltage-sensitive Na channels.
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Grilley Michelle M.
Olivera Baldomero M.
Shon Ki-Joon
Russel Jeffrey E.
University of Utah Research Foundation
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