Connective tissue growth factor (CTGF) regulatory nucleic acid s

Details Connective tissue growth factor (CTGF) regulatory nucleic acid s Connective tissue growth factor (CTGF) regulatory nucleic acid s

1998-04-02

2000-05-30

Spector, Lorraine

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 241, 4352523, 43525411, 935 6, C07H 2104

Patent

active

060690062

ABSTRACT:
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.

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Igarashi et al., "Regulation of Connective Tissue Growth Factor Gene Expression in Human Skin Fibroblast and During Wound Repair," Molecular Biology of the cell, vol. 4:637-645, Jun. 1993.

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