Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2008-07-29
2008-07-29
Haddad, Maher M. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388100, C530S388230
Reexamination Certificate
active
07405274
ABSTRACT:
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
REFERENCES:
patent: 5408040 (1995-04-01), Grotendorst et al.
patent: 5783187 (1998-07-01), Grotendorst et al.
patent: 6562618 (2003-05-01), Tamatani et al.
patent: 1 043 335 (2000-10-01), None
patent: WO 99/07407 (1999-02-01), None
patent: WO 99/13910 (1999-03-01), None
patent: WO 00/13706 (2000-03-01), None
patent: WO 00/35936 (2000-06-01), None
patent: WO 00/35939 (2000-06-01), None
patent: WO 03/024308 (2003-03-01), None
patent: WO 03/049773 (2003-06-01), None
Mercurio et al. Development. 2004. 131;9:2137-2147.
Lederman et al. Molecular Immunology 1991. 28: 1171-1181.
Li et al. PNAS 1980. 77: 3211-3214.
Li et al. Biochemistry 2000. 39:6296-6309.
Padlan et al. FASEB J. 1995. 9:133-139.
Wright et al. TIBTECH. 1997. 15:26-32.
Kang et al. PNAS 1991 88:11120-11123.
Steffen et al. (1998) Growth Factors 15(3):199-213.
Shimo et al. (2001) Oncology 61:315-322.
Duncan et al. (1999) Connective Tissue Growth Factor Mediates Transforming Growth Factor beta-induced Collagen Synthesis: Down Regulation by cAMP. FASEB J 13:1774-1786.
Usinger et al. (2003) TGFbeta2 Binds CTGF Specifically and is Inhibited by a CTGF Neutralizing Antibody, FG-3019. J Am Soc Nephrol 14:374A.
Lin Al Y.
Neff Thomas B.
Oliver Noelynn A.
Usinger William R.
Wang Qingjian
Dahle Chun
Fibrogen Inc.
Haddad Maher M.
Turner Christopher
LandOfFree
Connective tissue growth factor antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Connective tissue growth factor antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Connective tissue growth factor antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2789846