Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2008-06-10
2008-06-10
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S158100, C530S399000
Reexamination Certificate
active
07384634
ABSTRACT:
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF and polynucleotides regulating CTGF expression. The invention also provides agents that modulate CTGF and therapeutic methods for using the agents. Also provided are diagnostic methods for using CTGF and assays for identifying agents which affect the expression of CTGF polynucleotide.
REFERENCES:
patent: 4806523 (1989-02-01), Bentz et al.
patent: 4808402 (1989-02-01), Leibovich et al.
patent: 5094941 (1992-03-01), Hart
patent: 5147294 (1992-09-01), Smith et al.
patent: 5149691 (1992-09-01), Rutherford
patent: 5356630 (1994-10-01), Laurencin et al.
patent: 5399361 (1995-03-01), Song et al.
patent: 5408040 (1995-04-01), Grotendorst et al.
patent: 5418135 (1995-05-01), Pang
patent: 5693607 (1997-12-01), Segarini et al.
patent: 5770209 (1998-06-01), Grotendorst et al.
patent: 5783187 (1998-07-01), Grotendorst et al.
patent: 5837258 (1998-11-01), Grotendorst et al.
patent: 6331298 (2001-12-01), Ferguson et al.
patent: 7105305 (2006-09-01), Williams et al.
Abou-Shady et al. “Connective Tissue Growth Factor in Human Liver Cirrhosis,”Liver. 20:296-304 (2000) Munksgaard.
Allen et al. “Enhanced Insulin-Like Growth Factor Binding Protein-Related Protein 2 (Connective Tissue Growth Factor) Expression in Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis,”Am. J. Respir. Cell Mol. Biol. 21:693-700 (1999).
Bradham et al. “Connective Tissue Growth Factor: A Cysteine-rich Mitogen Secreted by Human Vascular Endothelial Cells is Related to the SRC-induced Immediate Early Gene Product CEF-10,”Journal of Cell Biology114(6):1285-1294 (1991) Rockefeller University Press.
Chen et al. “CTGF Expression is Induced by TGF-β in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis.”J Mol Cell Cardiol, 32:1805-1819 (2000).
di Mola et al. “Connective Tissue Growth Factor Is a Regulator for Fibrosis in Human Pancreatitis,”Annals of Surgery230(1):63-71 (1999) Lippincott Williams & Wilkins, Inc.
Duncan et al. “Connective Tissue Growth Factor Mediates Transforming Growth Factor β-induced Collagen Synthesis: Down-Regulation by camp,”FASEB J. 13:1774-1786 (1999).
Frazier and Grotendorst. “Expression of Connective Tissue Growth Factor mRNA in the Fibrous Stroma of Mammary Tumors,”Int. J. Biochem Cell Biol. 29:153-161 (1997) Elsevier Science Ltd.
Frazier et al. “Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor,”J Invest Dermatol107:404-411 (1996) Society; for investigative Dermatology, Inc.
Grotendorst. “Connective Tissue Growth Factor: A Mediator of TGF-β Action on Fibroblasts,”Cytokine&Growth Factor Reviews8(3):171-179 (1997) Elsevier Science Ltd.
Igarashi et al. “Differential Expression of Connective Tissue Growth Factor Gene in Cutaneous Fibrohistiocytic and Vascular Tumors,”J Cutan Pathol25:143-148 (1998) Munksgaard.
Igarashi et al. “Connective Tissue Growth Factor Gene Expression in Tissue Sections from Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders,”J Invest Dermatol106:729-733 (1996) Society; for Investigative Dermatology, Inc.
Ito et al. “Expression of Connective Tissue Growth Factor in Human Renal Fibrosis,” Department of Pathology, University of Amsterdam, pp. 853-861, (1997) International Socieity of Nephrology.
Kasaragod et al. “Connective Tissue Growth Factor Expression in Pediatric Myofibroblastic Tumors,”Pediatric and Developmental Pathology4:37-45 (2001) Society for Pediatric Pathology.
Kikuchi et al. “Expression of Fibrogenic Cytokines in Desmoplastic Malignant Melanoma,”British Journal of Dermatology139:192-197 (1998) British Association of Dermatologists.
Lasky et al. “Connective Tissue Growth Factor mRNA Expression is Upregulated in Bleomycin-induced Lung Fibrosis,”Am J Physiol275:L365-L371 (1998) American Physiological Society.
Lee and Joo. “Role of Transforming Growth Factor-β in Transdifferentiation and Fibrosis of Lens Epithelial Cells,”Invest Ophthal&Vis Sci40:2025-2032 (1999) Association for Research in Vision and Ophthalmology.
Mori et al. “Role and Interaction of Connective Tissue Growth Factor with Transforming Growth Factor-β in Persistent Fibrosis: A Mouse Fibrosis Model.”J. Cellular Physiology181:153-159 (1999) Wiley-Liss, Inc.
Oemar et al. “Human Connective Tissue Growth Factor is Expressed in Advanced Atherosclerotic Lesions,”Circulation95:831-839 (1997) American Heart Association, Inc.
Ohnishi et al. “Increased Expression of Connective Tissue Growth Factor in the Infared Zone of Experimentally Induced Myocardial Infarction in Rats,”J Mol Cell Cardiol30:2411-2422 (1998) Academic Press.
Paradis et al. “Expression of Connective Tissue Growth Factor in Experimental Rat and Human Liver Fibrosis,”Hepatology30:968-976 (1999).
Querfeld et al. “Pseudoscleroderma Associated with Lung Cancer: Correlation of Collagen Type I and Connective Tissue Growth Factor Gene Expression,”British Journal of Dermatology142:1228-1233 (2000) British Association of Dermatologists.
Sato et al. “Serum Levels of Connective Tissue Growth Factor Are Elevated in Patients with Systemic Sclerosis: Association with Extent of Skin Sclerosis and Severity of Pulmonary Fibrosis,”Journal of Rheumatology17:149-154 (1998).
Shi-wen et al. “Autocrine Overexpression of CTGF Maintains Fibrosis: RDA Analysis of Fibrosis Genes in Systemic Sclerosis,”Experimental Cell Research259:213-224 (2000) Academic Press.
Shimo et al. “Connective Tissue Growth Factor Induces the Proliferation, Migration, and Tube Formation of Vascular Endothelial Cells In Vitro, and Angiogenesis In Vivo,”J. Biochem.126:137-145 (1999) Japanese Biochemical Society.
Vorwek et al. “CTGF (IGFBP-rP2) Is Specifically Expressed in Malignant Lymphoblasts of patients with Acute Lymphoblastic Leukaemia (ALL),”British Journal of Cancer68(6):756-760 (2000) Cancer Research Campaign.
Wenger et al. “Expression and Differential Regulation of Connective Tissue Growth Factor in Pancreatic Cancer Cells,”Oncogene18:1073-1080 (1999) Stockton Press.
Bang et al., “Cyclic AMP induces transforming growth factor β2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3,”Proc. Natl. Acad. Sci. USA, 89:3556-3560 (1992).
Grotendorst et al., “A Novel Transforming Growth Factor β Response Element Controls the Expression of the Connective Tissue Growth Factor Gene,”Cell Growth and Differentiation, 7(4):469-480 (1996).
Igarashi et al., “Regulation of Connective Tissue Growth Factor Gene Expression on Human Skin Fibroblasts and During Wound Repair,”Molecular Biology of the Cell, 4(6):637-645 (1993).
Inagaki et al., “Transforming Growth Factor-β stimulates α2(I) Collagen Gene Expression through acis-Acting Element That Contains an Sp1-binding Site,”J. Biol. Chem., 269(20):14828-14834 (1994).
Keeton et al., “Identification of Regulatory Sequences in the Type 1 Plasminogen Activator Inhibitor Gene Responsive to Transforming Growth Factor β,”Journal of Biological Chemistry, 266(34):23048-23052 (1991).
Rundhaug and Nettesheim, “Growth Regulation of Primary Rat Tracheal Epithelial Cell Cultures by Endogenous Transforming growth Factor-βs,”J. Cellular Physiology, 155(3):483-493 (1993).
Ryseck et al., “Structure, Mapping, and Expression offisp-12, A Growth Factor-Inducible Gene Encoding a Secreted Cysteine-Rich Protein,”Cell Growth and Differentiation, 2(5):225-233 (1991).
Wilson et al., “2.2 Mb of contiguous nucleotide sequence from chromosome III ofC. eleganc
Bradham, Jr. Douglass M.
Grotendorst Gary R.
DLA Piper (US) LLP
Spector Lorraine
University of South Florida
LandOfFree
Connective tissue growth factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Connective tissue growth factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Connective tissue growth factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2805167