Fluent material handling – with receiver or receiver coacting mea – Filling means with receiver or receiver coacting means – With puncturing connecting means
Patent
1999-02-09
2000-06-06
Douglas, Steven O.
Fluent material handling, with receiver or receiver coacting mea
Filling means with receiver or receiver coacting means
With puncturing connecting means
141 27, 604200, 604201, 604403, 604406, B65B 104
Patent
active
060706236
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention generally relates to the connection between, on the one hand, a first receptacle comprising a neck obturated by a visco-elastic stopper capable of being perforated, and, on the other hand, a second receptacle comprising a muff joint (male element).
More particularly, but not exclusively, the present invention will be introduced, defined and described with reference to the connection between, on the one hand, a first receptacle constituted by a rigid flask, for example made of glass, of which the neck is hermetically obturated by a rubber stopper adapted to be perforated, and, on the other hand, a second, likewise rigid receptacle, constituted by a syringe, itself conventionally comprising a rigid tubular body terminating in a muff joint, of the "luer lock" type for example, and a plunger mounted to slide hermetically inside the tubular body. A connection as defined hereinbefore is required in particular when it is question of preparing a medicamentous solution or suspension from an active ingredient in the form of powder or lyophilizate, contained in the first receptacle, namely the flask, and from a liquid medium, for example a solution, contained in the second receptacle, i.e. in the syringe. In such a case, the following operations are generally carried out:
SUMMARY
(syringe) being filled with the liquid medium, the stopper is perforated with an appropriate perforating means, belonging to the syringe or not, in order to establish a communication between the two receptacles; the first receptacle (flask) in order to mix the liquid medium and the active ingredient in powder or lyophilizate form, the syringe being in that case disposed above the flask, complete, the assembly constituted by the flask and the syringe, connected to each other via the perforating means, is turned over in order to dispose the first receptacle above the second receptacle, the active ingredient is extracted from the first receptacle and introduced in the second recptacle, is then ready to be used, possibly after an injection needle has been positioned on the muff joint of said syringe.
In order to connect two receptacles such as defined and exemplified hereinabove, in accordance with document EP-A-0 126 718, a transfer device with perforation of the stopper has already been proposed, comprising: of the "luer lock" type, for tight join with the muff joint of the second receptacle, and, on the other hand, a filtering chamber isolated with respect to the outside by a filter, for example an absolute filter making it possible to sterilize any gaseous or liquid flow traversing it in one direction or in the other, communication between the inside of the first receptacle and the faucet and the filtering chamber respectively, in the position where the perforating means perforates the stopper, tightly with respect to the outside.
This connection device further comprises means for displacing with guidance the perforating means, constituted at least by a skirt forming an internal bore; at a fastened position in which the internal bore opens out on the stopper; fastened position of the skirt; in order to slide by simple pressure, from an inactivated position in which the perforating end is spaced apart from the stopper, to a perforating position in which this same perforating end has passed through the stopper.
Such a device allows any non-controlled relative movement between the two receptacles in the course of connection or connected, with the result that it is difficult to master with precision the quantity of liquid medium or liquid, introduced in the first receptacle or extracted therefrom, by means of the relative movement between the plunger and the tubular body of the syringe (second receptacle) for example.
The present invention therefore has for its object a solution making it possible better to control the relative movement between the first receptacle and the second receptacle, when they are connected, so as in particular to minimize and to render constant the dead volume, i.e. liqui
REFERENCES:
patent: 3940003 (1976-02-01), Larson
patent: 3977555 (1976-08-01), Larson
patent: 4576211 (1986-03-01), Valentini et al.
patent: 5636660 (1997-06-01), Pfleiderer et al.
Biodome
Douglas Steven O.
Maust Timothy L.
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