Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-09-09
1999-12-07
Celsa, Bennett
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530300, 530322, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 4241851, 4241931, 4241941, 42419511, A61K 3814, C07K 400
Patent
active
059983620
ABSTRACT:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA), hydrophilic oligopeptide blocking groups and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
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Feng Dong-Mei
Garsky Victor M.
Jones Raymond E.
Wai Jenny M.
Celsa Bennett
Daniel Mark R.
Merck & Co. , Inc.
Muthard David A.
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