Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-07-09
2000-10-03
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 530329, 530330, 540478, A61K 3800
Patent
active
061273333
ABSTRACT:
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide and vinblastine. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
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Brady Stephen F.
Garsky Victor M.
Pawluczyk Joseph M.
Daniel Mark R.
Delacroix-Muirheid C.
Jones Dwayne C.
Merck & Co. , Inc.
Muthard David A.
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