Conjugates useful in ameliorating autoimmunity MHC-II-peptide

Details Conjugates useful in ameliorating autoimmunity MHC-II-peptide Conjugates useful in ameliorating autoimmunity MHC-II-peptide

1990-08-30

1992-07-14

Nucker, Christine

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514825, 514903, 530395, 530403, 530838, A61K 3528, A61K 3702

Patent

active

051302977

ABSTRACT:
The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHC--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen; -- represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and -- represents a covalent bond, to noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.

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