Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-06-28
2011-06-28
Carlson, Karen Cochrane (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
07968512
ABSTRACT:
The subject invention pertains to a conjugate comprising: (a) a first region comprising the homeodomain of antennapedia or a variant thereof; and (b) a second region not naturally associated with the first region. In one embodiment, the second region of the conjugate comprises a protein of at least 100 amino acids.
REFERENCES:
patent: WO 97/12912 (1997-04-01), None
Saffman et I. 1994; A differential response element for the homeotics at the antennapedia P1 promoter of Drosophila. Proc. Natl. Acad. Sci. 91: 7420-7424.
Perez et al. 1994; Rab3A and Rab3B carbosy-terminal peptides are both potent and specific inhibitors of prolactin release by rat cultured anterior pituitary cells. Mol. Endocrin. 8: 1278-1287.
Prochiantz, A. “Getting hydrophilic compounds into cells: lessons from homeopeptides”Current Opinion in Neurobiology, 1996, pp. 629-634, vol. 6, No. 5.
Derossi, D. et al. “Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent”Journal of Biological Chemistry, 1996, pp. 18188-18193, vol. 271, No. 30.
Schutze-Redelmeier, M-P et al. “Introduction of exogenous antigens into the MHC class I processing and presentation pathway by Drosophila antennapedia homeodomain primes cytotoxic T cells in vivo”Journal of Immunology, 1996, pp. 650-655, vol. 157, No. 2.
Bonfanti, M. et al. “p21 WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth”Cancer Research, 1997, pp. 1442-1446, vol. 57.
Brugidou, J. et al. “The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: A new basis for an efficient intracellular delivery system”Biochemical and Biophysical Research Communications, 1995, pp. 685-693, vol. 214, No. 2.
Simmons, C.G. et al. (1997) “Synthesis and membrane permeability of pna-peptide conjugates”Bioorganic&Medicinal Chemistry Letters, 1997, pp. 3001-3006, vol. 7, No. 23.
Carlson Karen Cochrane
DLA Piper (LLP) US
Trojan Technologies Limited
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