Conjugates possessing ortho ligating functionality

Details Conjugates possessing ortho ligating functionality Conjugates possessing ortho ligating functionality

1996-02-06

1998-02-03

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562444, 562448, 534 10, 534 15, 534 16, C07C22900

Patent

active

057146314

ABSTRACT:
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.

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