Conjugates of vitamin B12 and proteins

Details Conjugates of vitamin B12 and proteins Conjugates of vitamin B12 and proteins

1994-07-29

1996-11-12

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424851, 424854, 514 8, 514 12, 530351, 530395, 530399, 530409, A61K 3168, A61K 3841, C07H 2300, C07K 1400

Patent

active

055740189

ABSTRACT:
Therapeutically useful proteins are conjugated to vitamin B.sub.12 by covalent binding at the primary hydroxyl site of the ribose moiety. The resulting conjugates are biologically active and can be formulated into pharmaceutical compositions suitable for delivery by various routes of administration, preferably oral. Uptake in the gut following oral delivery is further enhanced by the co-administration of purified intrinsic factor.

REFERENCES:
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patent: 5428023 (1995-06-01), Russell-Jones et al.
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Yamada et al., Journal of Biol. Chem., 247 (1972) No. 19, 6266-6270.
Chow et al., Am. Journ. Clin. Nutr., 6 (1958) No. 1, 30-33.
Olesen et al., Biochimica et Biophysica Acta, 243 (1971) 66-74.
Bioconjugate Chem., vol. 6, No. 4, pp. 459-465 (1995).

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