Conjugates of vinblastine, a process for their preparation and t

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin

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514 21, 530362, 530391, 530405, 530409, C07K 1706, C07K 1514, C07K 1500

Patent

active

048701629

ABSTRACT:
The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof.
These compounds correspond to the following general formula ##STR1## in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted --CO(CH.sub.2).sub.n CO-- or ##STR2## in which n is 1 to 5, R.sub.1 represents an optionally modified protein radical,

REFERENCES:
patent: 4522750 (1985-06-01), Ades et al.
patent: 4596676 (1986-06-01), Cullinan
patent: 4801688 (1989-01-01), LaGuzza et al.

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