Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1986-04-23
1989-09-26
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
514 21, 530362, 530391, 530405, 530409, C07K 1706, C07K 1514, C07K 1500
Patent
active
048701629
ABSTRACT:
The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof.
These compounds correspond to the following general formula ##STR1## in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted --CO(CH.sub.2).sub.n CO-- or ##STR2## in which n is 1 to 5, R.sub.1 represents an optionally modified protein radical,
REFERENCES:
patent: 4522750 (1985-06-01), Ades et al.
patent: 4596676 (1986-06-01), Cullinan
patent: 4801688 (1989-01-01), LaGuzza et al.
Bushana Kandukuri S.
Dejonghe Jean-Paul
Hannart Jean A. A.
Trouet Andre B. L.
Omnichem
Schain Howard E.
LandOfFree
Conjugates of vinblastine, a process for their preparation and t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Conjugates of vinblastine, a process for their preparation and t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates of vinblastine, a process for their preparation and t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-188350