Conjugates of superoxide dismutage coupled to high molecular wei

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 7837, 528405, 514886, A61K 31765

Patent

active

054684781

ABSTRACT:
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.

REFERENCES:
patent: 3337487 (1967-08-01), Nandenberg
patent: 4179337 (1979-12-01), Davis et al.
patent: 4563349 (1986-01-01), Miyata et al.
patent: 4917888 (1990-04-01), Katre et al.
patent: 5006333 (1991-04-01), Saifer et al.
patent: 5080891 (1992-01-01), Saifer et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5283317 (1994-02-01), Saifer et al.
Chem. Abstracts 116:106772 g Atassi et al.
Beauchamp, et al., "A New Procedure for the Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and 2-Macroglobulin," Analytical Biochemistry 131(1):25-33 (1983), Academic Press, New York.
Birkenmeier, et al., "Immobilized metal ion affinity partitioning, a method combining metal-protein interaction and partitioning of proteins in aqueous two-phase systems, " Journal of Chromatography 539:267-277 (1991).
Boccu, et al., "Coupling of Monomethozypolethyleneglycols to Proteins via Active Esters, " Z. Naturforsch 38:94-99 (1983).
Boccu, et al., "Pharmacokinetic Properties of Polyethylene Glycol Derivated Superoxide Dismutase, " Pharmacological Research Communications 14:113-120 (No. 2) (1982).
Buckmann, et al., "Preparation of Technical Grade Polyethylene Glycol (PEG) M.sub.r 20,000)-N .sup.6 -(2-Aminoethyl)-NADH by a Procedure Adaptable to Large-Scale Synthesis, " Biotechnology and Applied Biochemistry 9:258-268 (1987).
Derwent Abstract, DE-4014260-A, "New Hirudin-Polyalkylene Glycol Conjugates".
Mueller, et al., "Studies of Chemically Modified Honeybee Venom, " Int. Archs. Allergy Appl. Immun., 68:312-319 (1982).
Mueller, et al., "Studies of Chemically Modified Honeybee Venom, " Int. Archs. Allergy Appl. Immun. 68:320-325 (1982).
Mutter et al., "Functionalized Polyethylene Glycols and Polypeptides in Organic Synthesis and Catalysis, " Reactive Polymers 6:99-107 (1987).
Pyatak, et al., "Preparation of a Polyethylene Glycol: Superoxide Dismutase Adduct, and an Examination of its Blood Circulating Life and Anti-Inflammatory Activity, " Res. Commun. Chem. Pathol. Pharmacol. 29(1):113-127 (1980).
Richter, et al., Int. Archs. Allergy Appl. Immun. 70:124-131 (1983).
Sims, et al., "A Method for the Estimation of Polyethylene Glycol in Plasma Protein Fractions, " Anal. Biochem. 107:60-63 (1980).
Veronese, et al., "Surface Modification of Proteins, " Appl. Biochem. Biotech. 11:141-152 (1985). Weng, et al., "Suppression of Reaginic Antibodies with Modified Allergens, " Int. Archs. Allergy Appl. Immun. 56:159-170 (1978).
Weng, et al., "Suppression of Reaginic Antibodies with Modified Allergens, " Int. Archs. Allergy Appl. Immun. 56:193-206 (1978).
Weng, et al., "Suppression of Reaginic Antibodies with Modified Allergens, " Int. Archs. Allergy Appl. Immun. 64:100-114 (1981).
Wie, et al., "Suppression of Reaginic Antibodies with Modified Allergens, " Int. Archs. Allergy Appl. Immun. 64:84-99 (1981).
Yoshimoto, et al., "Characterization of Polyethylene Glycol-Modified L-Asparaginase from Escherichia Coli and Its Application to Therapy of Leukemia, " Jpn. J. Cancer Res. (Gann) 77:1264-1270 (1986).
Zalipsky et al., "Attachment of Drugs to Polyethylene Glycols, " Eur. Polym. J. 19:1177-1183 (1983).
Zalipsky, et al., "A convenient general method for systhesis of N.alpha.-or N.omega.-dithiasuccionoyl (Dts) amino acids and dipeptides: application of polyethylene glycol as a carrier for functional purification," Int. J. Peptide Protein Res. 30:740-783 (1987).
"Polyethers (Ethylene Oxide Polymers)," Kirk-Othmer Encyclopedia of Chemical Technology, vol. 18 3rd Ed. , John Wiley & Sons, Publ. 616-632 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Conjugates of superoxide dismutage coupled to high molecular wei does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugates of superoxide dismutage coupled to high molecular wei, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates of superoxide dismutage coupled to high molecular wei will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1135231

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.