Conjugates of sulforhodamine fluorophores with enhanced fluoresc

Details Conjugates of sulforhodamine fluorophores with enhanced fluoresc Conjugates of sulforhodamine fluorophores with enhanced fluoresc

1996-07-26

1998-12-08

Wilson, James O.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 75, 435 772, 435 78, 436501, 436544, 436546, 436800, 530300, 5303871, 5303889, 5303913, 5303919, 536 231, 536 251, 536 252, 536 2532, 536 2626, 536 266, 536 267, 536 268, 549229, 549227, 549394, G01N 33533, C07K 1600, C07D31188

Patent

active

058467378

ABSTRACT:
The invention describes useful conjugates of sulforhodamine, wherein the conjugated substance and the fluorophore are separated by an alkanoic acid spacer that is attached to the fluorophore via a sulfonamide bond. The increased length of the covalent linkage due to the spacer results in dye-conjugates having a number of surprisingly advantageous properties relative to previous sulforhodamine-labeled conjugates, including increased fluorescence.

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