Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-12-18
1999-02-16
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303896, 53038875, C07K 1600
Patent
active
058722220
ABSTRACT:
Disclosed are conjugates including a substantially nonimmunogenic polymer backbone or microbead and binding molecules, such as Fv, Fab, or F(ab').sub.2 fragments of monoclonal antibodies or whole antibodies that are bound through their Fc carbohydrate moieties or have their Fc portion modified so that they cannot effect ADCC or complement-mediated cytolysis, and that are specific for a T cell surface antigen, such as CD3, TCR, CD4, CD8, or CD28 on T cells. The polymer or microbead is preferably made of cross-linked dextran, ficoll, latex, or agarose, and is preferably of 0.1 to 10 .mu.m in size, so that it can be suspended in fluids for in vivo applications. These conjugates can be used as adjuvants to enhance the antibody response against an administered immunogen.
REFERENCES:
Paul Fundamental Immunology Raven Press (1989) p. 364.
Verwilghen et al Immunology 72:269-276 1991.
Geppert et al , 138:1660-1666, 1987, Journal of Immunology.
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Ceuppens et al. J.I. 137:1816-1821 1986.
Eisenschenk Frank C.
Mirabel Eric P.
Tanox Biosystems, Inc.
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