Conjugates of mycophenolic acid

Details Conjugates of mycophenolic acid Conjugates of mycophenolic acid

2007-06-26

2007-06-26

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10900447

ABSTRACT:
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.

REFERENCES:
patent: 1595101 (1926-08-01), Tonkes et al.
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 4273866 (1981-06-01), Voss et al.
patent: 4341865 (1982-07-01), Voss
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 5352803 (1994-10-01), Mattingly
patent: 5493030 (1996-02-01), Morgans, Jr. et al.
patent: 5496925 (1996-03-01), Mattingly
patent: 5512568 (1996-04-01), Morgans, Jr. et al.
patent: 5525602 (1996-06-01), Patterson et al.
patent: 5538969 (1996-07-01), Morgans, Jr. et al.
patent: 5554612 (1996-09-01), Patterson et al.
patent: 5573904 (1996-11-01), Mattingly
patent: 5616298 (1997-04-01), Mattingly
patent: 5633279 (1997-05-01), Morgans, Jr. et al.
patent: 5756771 (1998-05-01), Mattingly
patent: 5807876 (1998-09-01), Armistead et al.
patent: 6107052 (2000-08-01), Dorn
patent: 6225073 (2001-05-01), Alexander et al.
patent: 6524808 (2003-02-01), Dorn et al.
patent: 6811998 (2004-11-01), Ghoshal et al.
patent: 1 054 258 (2000-11-01), None
patent: 1207394 (2002-05-01), None
patent: WO 97/41211 (1997-11-01), None
patent: WO 99/33996 (1999-07-01), None
patent: WO 01/01135 (2001-01-01), None
patent: WO 01/01135 (2001-01-01), None
patent: 0101135 (2001-04-01), None
Dorn, Allan et al., Abstract of Oak Ridge Posters, Clinical Chemistry 47, No. 10 (2001) p. 1921-1922.
Nelson, P.H. et al. “Structure-Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid,” J. Med. Chem., 1996, 39, 4181-4196.
Nelson, P.H. et al., “Synthesis and Immunosuppressive Activity of Some Side-Chain Variants of Mycophenolic Acid,” J. Med. Chem, 1990, 33, 833-838.
Smith, D.B. et al., “Asymmetric Synthesis and Stereochemical Assignment o RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent,” J. Org. Chem., 1996, 61, 2236-2241.
Zhang, Han-Zhong et al., “Rationally Designed Inhibitors of Inosine Monophosphate Dehydrogenase,” J. Med. Chem., 1997, 40, 4-8.
Carr, S.F., Papp, E., Wu, C., Natsumeda, Y., “Characterization of Human Type I and Type II IMP Dehydrogenases” Journal of Biological Chemistry. vol. 268, No. 36, 1993, 27286-27290.
Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P. “Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid”. Cell, vol. 85, 921-930, Jun. 14, 1996.
Ross, R., Horwitz, C.A., Hager, H., Usategui, M., Burke, M.D., Ward, P.C.J. “Preliminary Evauation of a Latex Agglutination-Inhibition Tube Test for Morphine”, Clin. Chem. 21/1, 139-143, 1975.
Clark, B.R., Deshpande, S.V., Sharma, S.D., Nag, B. “Antigen-specific Deletion of Cloned T Cells Using Peptide-Toxin Conjugate Complexed with Purified Class II Major Histocompatibility Complex Antigen”. Journal of Biological Chemistry, vol. 269, No. 1, Issue of Jan. 7, 1994, pp. 94-99.
Place, M.A., Carrico, R.J., Yeager, F.M., Albarella, J.P., Boguslaski, R.C. “A Colorimetric Immunoassay Based on an Enzyme Inhibitor Method”. Journal of Immunological Methods, 61, (1983), 209-216.
Bacquet, C, and Twumasi, D.Y. “Homogeneous Enzyme Immunoassay with Avidin-Ligand Conjugate as the Enzyme-Modulator.” Analytical Biochemistry 136, (1984), 487-490.
Finley, P.R., Williams, R.J., Lichti, D.A. “Evaluation of a New Homogeneous Enzyme Inhibitor Immunoassay of Serum Thyroxine with Use of a Bichromatic Analyzer”, Clin. Chem. 26/12, 1723-1726, (1980).
Nimmesgern, E., Fox, T., Fleming, M.A., Thomson, J.A. “Conformational Changes and Stabilization of Inosine 5'-Monophosphate Dehydrogenase Associated with Ligand Binding and Inhibition by Mycophenolic Acid”, The Journal of Biological Chemistry, 1996, vol. 271, No. 32, pp. 19421-19427.

Affiliated with

Also associated with

Rating

Conjugates of mycophenolic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugates of mycophenolic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates of mycophenolic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3882370