Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-15
1999-09-21
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 245, C07H 2100, C07H 2104
Patent
active
059555904
ABSTRACT:
Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization complexes with DNA and can be used for any purpose which involves hybridizing an oligonucleotide to a DNA molecule, such as in antisense procedures. A method for enhancing oligonucleotide binding to a target is also provided. The method involves the step of hybridizing the target DNA with an oligonucleotide-peptide composition.
REFERENCES:
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5258507 (1993-11-01), Cruickshank et al.
patent: 5405938 (1995-04-01), Summerton et al.
patent: 5437977 (1995-08-01), Segev
patent: 5446137 (1995-08-01), Maag et al.
patent: 5466786 (1995-11-01), Buhr et al.
patent: 5493012 (1996-02-01), Bokita et al.
patent: 5514786 (1996-05-01), Cook et al.
patent: 5519126 (1996-05-01), Hecht
patent: 5693463 (1997-12-01), Edwards et al.
patent: 5716780 (1998-02-01), Edwards et al.
patent: 5738990 (1998-04-01), Edwards et al.
patent: 5744131 (1998-04-01), Edwards et al.
patent: 5786138 (1998-07-01), Swenson
Lown, JW., "DNA Recognition by Lexitropsins, Minor Groove Binding Agents", J Mol. Rec., (1994), 7:79-88.
Lukhtanov, EA., et al., "Oligodeoxyribonucleotides with Conjugated Dihydropyrroloindole Oligopeptides: . . . Properties", Bioconjugate Chem, (1995), 6:418-426.
Levina, A., et al., "Conjugates of Minor Groove DNA Binders with Oligodeoxynucleotides: Synthesis and Properties", Antisense & Nucleic Drug Development, (1996), 6:75-85.
Waring, M., et al., "Binding of Antibiotics to DNA", Host-Guest Molecular Interactions: From Chemistry to Biology / Wiley, Chichester (Ciba Foundation Symposium 158), 1991, pp. 128-146.
Lown, William, J., "DNA Recognition by Lexitropsins, Minor Groove Binding Agents", Journal of Molecular Recognition, 1994, 7:79-88.
Pilch, D., et al., "Ligand-induced formation of nucleic acid triple helices", Proc. Natl. Acad. Sci., 1994, 91:9332-9336.
Wittung, P., et al., "Interactions of DNA binding ligands with PNA-DNA hybrids", Nucleic Acids Research, 1994, 22:24:5371-5377.
Sinyakov, A., et al., "Exceptional and Selective Stabilization of A-T Rich DNA-DNA Duplexes by N-Methylpyrrole Carboxamide Peptides Conjugated to Oligodeoxynucleotides". Journal of the American Chemical Society, 1995, 117: 4995-4996.
Levina Asya
Zamecnik Paul C.
Elliott George C.
Larson Thomas G.
Worcester Foundation for Biomedical Research
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