Conjugates of methyltrithio antitumor agents and intermediates f

Details Conjugates of methyltrithio antitumor agents and intermediates f Conjugates of methyltrithio antitumor agents and intermediates f

1994-06-03

1998-06-30

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

514 25, 514 53, 514 54, 514 61, 514 69, 5303911, 530402, 536 168, A61K 39395, C07K 1600, C07G 1100

Patent

active

057730016

ABSTRACT:
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

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