Conjugates of leukotrienes with proteins

Details Conjugates of leukotrienes with proteins Conjugates of leukotrienes with proteins

1986-05-05

1988-08-30

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530402, A61K 3702, C07K 1700

Patent

active

047677457

ABSTRACT:
Leukotrienes may be conjugated with various proteins such as Bovine Serum Albumin (BSA) and Hemocyanin from Giant Keyhole Limpets (KLH) using 1,5-difluoro-2,4-dinitrobenzene or 6-N-maleimidohexanoic acid chloride as coupling agents.
These conjugates are useful as reagents in a newly developed immunoassay for leukotrienes, as well as having potential utility as chemical immunotherapeutic agents in the treatment of various allergic and chronic inflammatory diseases of the skin, lung, and airways, including asthma, allergic rhinitis, rheumatoid arthritis, and skin diseases such as psoriasis and eczema.

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Salmon, et al., Prostaglandins, vol. 24, No. 2, 225-235, (1982).
Lewis, et al., Proc. Natl. Acad. Sci., vol. 79, pp. 7904-7908, (1982).

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