Conjugates of haptenes and muramyl-peptides, endowed with immuno

Details Conjugates of haptenes and muramyl-peptides, endowed with immuno Conjugates of haptenes and muramyl-peptides, endowed with immuno

1983-03-11

1987-01-27

Wiseman, Thomas G.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

530322, 530300, 514 8, 514 14, 514 53, 514 54, 424 88, A61K 3900, A61K 3700

Patent

active

046395121

ABSTRACT:
The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, essentially in the absence of supporting macromolecules, this conjugate having an immunogenic effect not only against itself, but also with respect to the native antigen carrying said antigenic site.

REFERENCES:
patent: 4397844 (1983-08-01), Baschang et al.
Dreesman et al., Nature, vol. 295, Jan. 14, 1982, pp. 158-160, "Antibody to Hepatitis B Surface Antigen After a Single Inocculation of Uncoupled Synthetic HBsAg Peptides".
Bahr et al., Mol. Immunology, vol. 19(5), pp. 737-745, May 1982, "Analysis of the Antigenic Relationship of Various Derivatives of N-Acetyl-Muramyl-L-Ala-D-isoglutamine (MDP) Using Anti-MDP Antibodies".
Lerner et al., Proc. Natl. Acad. Sci., vol. 78(6), pp. 3403-3407, Jun. 1981, "Chemically Synthesized Peptides Predicted From the Nucleotide Sequence of the Hepatitis B . . . Dane Particles".
Matsuura et al., Endocrinology, vol. 104(2), "A Human Chorionic Gonadotropin-Specific Antiserum Against Synthetic Peptide Analogs to the Carboxyl-Terminal Peptide of Its .beta.-Subunit".
Reichert et al., Mol. Imm., vol. 17(3), Mar. 1980, pp. 357-363, "Synthesis of Conjugates Containing N-Acetylmuramyl-L-Alanyl-D-Isuglutaminyl (MDP) Their Use as Hapten-Carrier Systems".
Arnon et al., Proc. Natl. Acad. Sci., vol. 77, No. 11, Nov. 1980, pp. 6769-6772, "Antiviral Response . . . Peptide".
Mozes et al., Proc. Natl. Acad. Sci., vol. 77(8), Aug. 1980, pp. 4933-4937, "Efficient Genetically Controlled Formation of Antibody to a Synthetic Antigen . . . isogluatamine".
Carelli et al., (including J. Gaillard), Proc. Natl. Acad. Sci., vol. 79(17), pp. 5342-5395, "Immunological Castration of Male Mice by a Totally Synthetic Vaccine Administered in Saline".
Chedid et al., Infect. Immun., vol. 35(2), Feb. 1982, "Biological Activity of a New Synthetic Muramyl Peptide Devoid of Antigenicity".

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