Conjugates of folate anti-effector cell antibodies

Details Conjugates of folate anti-effector cell antibodies Conjugates of folate anti-effector cell antibodies

1995-05-05

1996-08-20

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241541, 4241731, 4241781, 435 7021, 4351722, 43524027, 5303917, 5303911, 53038875, 5303896, A61K 39395, C07K 1628, C21P 2108

Patent

active

055476686

ABSTRACT:
The present invention provides a process of targeting folate-receptor-positive tumor cells for lysis by binding a conjugate of folate and an anti-T-cell-receptor antibody or an anti-Fc receptor antibody to those cells. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-T-cell-receptor antibody in the presence of a population of T-cells is also provided. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-Fc receptor antibody in the presence of a population of natural killer cells, monocytes, or macrophages is also provided. Still further, the present invention provides a conjugate of folate to an anti-T-cell-receptor antibody or an anti-Fc receptor antibody.

REFERENCES:
patent: 5030719 (1991-07-01), Umemoto et al.
patent: 5070877 (1991-12-01), Mohiuddin et al.
patent: 5108921 (1992-04-01), Low et al.
patent: 5140104 (1992-08-01), Coughlin et al.
Fanger et al (1990). Faseg J. 4(11) 2846-2849.
Leaman et al (1993) J. Biol. Chem. vol. 268 (33) 24847-24854.
Brigle, K. E., Spinella, M. J., Westin, E. H. & Goldman, I. D. [1994] Biochem Pharmacol 47:337-345.
Brigle, K. E., Seither, R. L., Westin, E. H. & Goldman, I. D. [1994] Biol Chem 269:4267-4272.
Brigle, K. E., Westin, E. H., Houghton, M. T. & Goldman, I. D. [1991] J Biol Chem 266:17243-17249.
Campell, I. G., Jones, T. A., Foulkes, W. D., & Trowsdale, J. [1991] Cancer Res. 51:5329-5338.
Fanger, Morganelli, & Guyre [1992] Crit. Rev. Immunol. 12:101-1240.
Haskins, K., Hannum, C., White, J., Rhoem, N., Kubo, R., Kappler, J. & Marrack, K. [1984] J. Exp. Med. 160:452-471.
Jansen, G., Westerhof, G. R., Kathmann, I., Rademaker, B. C., Rijksen, G., & Schornagel, J. H.[1989] Cancer Res. 49:2455-2459.
Kranz, D. M., Sherman, D. H., Sitkovsky, M. V., Pasternack, M. S. & Eisen, H. N. [1984] Proc. Natl. Acad. Sci. USA 81:573-577.
Kranz, D. M., Tonegawa, S. & Eisen, H. N. [1984] Proc. Natl. Acad. Sci. USA 81:7922-7926.
Leamon, C. P. & Low, P. S. [1992] J Biol Chem 267:24966-24971.
Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. & Bluestone, J. A. [1987] Proc. Natl. Acad. Sci. USA 84:1374.
Miotti S., Canevari, S., Menard, S., Mezzanzanica, D., Porro, G., Pupa, S. M., Regazzoni, M., Tabliabue, E. & Colnaghi, M. I.[1987] Int. J. Cancer 39:297-303.
Ross et al., Cancer 73:2432, 1994.
Schodin, B. A. & Kranz, D. M. [1993] J. Biol. Chem. 268:25722-25727.
Soo Hoo, W. F. & Kranz, D. M. [1993] J. Immunol. 150:4331-4337.
Weitman et al., Cancer Research 52:3396, 1992.
Westerof, G. R., Jansen, G., Van Emmerik, N., Kathmann, I., Rijksen, G., Jackman, A. L. & Schornagel, J. H. et al. [1991] Cancer Research 51:5507-5513.

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