Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-09-06
2010-06-22
Tsang, Cecilia (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07741277
ABSTRACT:
The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
REFERENCES:
FDA Label for Avastin U.S. BL 125085/169 Amendment: Bevacizumab Genentech, Inc. May 2009.
Wipf et al. “Cellular Analysis of Disorazole C1 and Structure—Activity Relationship of Analogs of the Natural Product,” Chem Biol Drug Des 2006; 67: 66-73.
Guenther Eckhard
Paulini Klaus
Schaefer Olaf
Teifel Michael
Aeterna Zentaris GmbH
Bradley Christina
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Tsang Cecilia
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