Conjugates of D-glutamic acid: D-lysine copolymer and certain bi

Details Conjugates of D-glutamic acid: D-lysine copolymer and certain bi Conjugates of D-glutamic acid: D-lysine copolymer and certain bi

1988-10-06

1990-08-21

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

424 851, 424 858, 252645, C08H 100, C08L 8900, A61K 3900, C09K 1104

Patent

active

049507133

ABSTRACT:
Receptor blocking technology using proteins conjugated to polymers of D-glutamic acid and D-lysine for treatment of antibody-mediated autoimmune disease, membrane and tumor disorders is disclosed.

REFERENCES:
patent: 4191668 (1980-03-01), Katz
Chiorazzi et al, "Induction of Immunological Tolerance to the Major Antigenic Determinant of Penicillin: A Therapeutic Approach to Penicillin Allergy" Proc Natl Acad. Sci. U.S.A. vol. 73, No. 6, pp. 2091-2095, Jun. 1976.
Liu et al, "Immunological Tolerance to Allergenic Protein Determinants: A Therapeutic Approach for Selective Inhibition of IgE Antibody Production" Proc Natl Acad Sci U.S.A., vol. 76, No. 3, pp. 1430-1434, Mar. 1979.
Liu et al, "Immunologic Tolerance to Allergenic Protein Determinants: Properties of Tolerance Induced in Mice Treated with Conjugates of Protein and a Synthetic Copolymer of D-glutamic Acid and D-lysine (D-GL)" J. of Immunol. vol. 123, No. 6, 2456-2465, Dec. 1979.

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