Conjugates of biologically stable polymers and polynucleotides f

Details Conjugates of biologically stable polymers and polynucleotides f Conjugates of biologically stable polymers and polynucleotides f

1990-03-13

1992-11-10

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514885, C07H 1700

Patent

active

051625156

ABSTRACT:
Chemically defined conjugates of biologically stable polymers, such as copolymers of D-glutamic acid and D-lysine, and polynucleotide duplexes of at least 30 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies. The duplexes are preferably homogeneous in length and structure and are bound to the polymer via reaction between an amino-reactive functional group located at or proximate a terminus of each duplex. These conjugates are tolerogens for human systemic lupus erythematosus.

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