Conjugates of biologically stable polyfunctional molecules and p

Details Conjugates of biologically stable polyfunctional molecules and p Conjugates of biologically stable polyfunctional molecules and p

1992-07-15

1994-01-04

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 44, 536 242, 424 7802, 424 7824, 424 7831, A61K 3100, A61K 3170, C07H 1700

Patent

active

052760138

ABSTRACT:
Chemically defined conjugates of biologically stable valency platform molecules, such as copolymers of D-glutamic acid and D-lysine or polyethylene glycol, and polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies. The duplexes are preferably homogeneous in length structure and are bound to the valency platform molecule via reaction between a functional group located at or proximate a terminus of each duplex and functional groups on the valency platform molecule. These conjugates are tolerogens for human systemic lupus erythematosus.

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