Conjugates of antioxidants with metal chelating ligands for...

Details Conjugates of antioxidants with metal chelating ligands for... Conjugates of antioxidants with metal chelating ligands for...

2006-11-20

2008-08-05

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S001490

Reexamination Certificate

active

07407644

ABSTRACT:
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radiopharmaceutical complexes.

REFERENCES:
Beaupere, D. et al; “Selective Azidation of L Sorbose Application to the Rapid Synthesis of 1 Deoxynojirmycin”, Carbohydrate Research, vol. 191, No. 1, pp. 163-166, 1989.
Lewis, M et al.; “Maleimidocysteineamido-DOTA derivatives: New Reagents for Radiometal Chelate Conjugation to Antibody Sulfhydryl Groups”, Bioconjugate Chemistry, vol. 9, No. 1, Jan. 1998.
Ranganathan, R. et al.; “Synthesis of Conjugates of Ascorbic Acid with Metal Chelates”, Abstracts of Papers American Chemical Society, vol. 221, No. 1-2, p. Carb 59, 2001.
PCT Search Report for PCT/US01/46002 mailed Jun. 11, 2003.

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