Conjugates of anticoagulant and protein

Details Conjugates of anticoagulant and protein Conjugates of anticoagulant and protein

1986-09-09

1987-07-07

Foelak, Morton

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, 424101, 530350, 530362, 530363, 530382, 530386, 530402, 514 2, 514 56, 514802, 514822, 436524, 536 21, 428375, 428141, A61K 3700, C07C10352

Patent

active

046786716

ABSTRACT:
Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

REFERENCES:
patent: 3099600 (1963-07-01), Toccaceli
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4003792 (1977-01-01), Mill et al.
patent: 4082507 (1978-04-01), Sawyer
patent: 4110432 (1978-08-01), Wilkinson et al.
patent: 4326532 (1982-04-01), Hammar
patent: 4329383 (1982-05-01), Joh
patent: 4342739 (1982-08-01), Kakimi et al.
Article, Chemical Abstracts, vol. 77, No. 17003r, p. 296, Jul., 1972, Yunosov, R. V.
Article, Thrombosis Research, vol. 7, 1975, pp. 273-284, Teien et al.

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