Conjugates of anticoagulant and protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530362, 530363, 530382, 530386, 514 2, 514 56, 514802, 514822, 536 21, 424101, C08B 3710

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active

046347623

ABSTRACT:
Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

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Article, Chemical Abstracts, vol. 77, No. 17003r, p. 296, Jul. 1972, Yunosov, R.V.
Article, Thrombosis Research, vol. 7, 1975, pp. 273-284, Teien et al.

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