Conjugates of anticoagulant and protein

Details Conjugates of anticoagulant and protein Conjugates of anticoagulant and protein

1982-12-13

1985-07-02

Foelak, Morton

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 260121, 424 16, 424 36, 424101, 514 56, 514 2, 514802, 514822, 436524, 536 21, C08B 3710

Patent

active

045267146

ABSTRACT:
Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

REFERENCES:
patent: 3099600 (1963-07-01), Toccaceli
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4003792 (1977-01-01), Mill et al.
patent: 4082507 (1978-04-01), Sawyer
patent: 4326532 (1982-04-01), Hammar
patent: 4329383 (1982-05-01), Joh
patent: 4342739 (1982-08-01), Kakimi et al.
Chemical Abstracts, vol. 77, No. 3, Jul. 17, 1972 (Columbus, Ohio) R. V. Yunusov "Complexing of Heparin with Plasma Proteins", Second p. 296, Paragraph 17003r, Vop. Med. Khim 1972, vol. 18, No. 2, pp. 189-191.
Thrombosis Research, vol. 7, 1975, pp. 273-284, Teien et al.

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