Conjugates of antibodies and bifunctional ligands

Details Conjugates of antibodies and bifunctional ligands Conjugates of antibodies and bifunctional ligands

1993-03-29

1997-03-18

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 153, 5303915, 530402, 530408, 530409, 5303913, A61K 5110

Patent

active

056120168

ABSTRACT:
Provided are conjugates useful in cancer, cardiovascular or infectious disease detection and/or therapy. The conjugate is of a ligand and protein. The ligand has a moiety capable of binding to mercapto groups and is capable of chelating a metal useful for detection or therapy. The protein reacts with a substance associated with a targeted cell, pathologic lesion or pathogen. The protein prior to conjugation has at least one mercapto group which becomes a site for conjugation to the ligand. Also provided are metal chelates of the conjugate, methods of detection and therapy, methods for producing the conjugate and pharmaceuticals compositions of the conjugates.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4454106 (1984-06-01), Ganson et al.
patent: 4647655 (1987-03-01), Axen et al.
patent: 4659839 (1987-04-01), Nicolotti
patent: 4837003 (1989-06-01), Nicolotti
patent: 5102990 (1992-04-01), Rhodes
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5128119 (1992-07-01), Griffiths
patent: 5134071 (1992-07-01), Gaetjens
patent: 5180816 (1993-01-01), Dean
patent: 5247075 (1993-09-01), Parker et al.
patent: 5354554 (1994-10-01), Rhind
patent: 5514363 (1996-05-01), Shochat et al.

Affiliated with

Also associated with

Rating

Conjugates of antibodies and bifunctional ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugates of antibodies and bifunctional ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates of antibodies and bifunctional ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1704076