Conjugates of a vinca derivative carrying a detergent chain in t

Details Conjugates of a vinca derivative carrying a detergent chain in t Conjugates of a vinca derivative carrying a detergent chain in t

1989-02-03

1991-06-18

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

530324, 530363, 530391, 530395, 530399, 530409, 514 12, 514 21, A61K 3944, A61K 3736, A61K 3704, C07K 1700

Patent

active

050248359

ABSTRACT:
The subject of the present invention is conjugates of vinca (indole-dihydroindole) derivatives carrying a detergent chain of at least 7 aliphatic carbon atoms in the C-3 position bonded via a covalent bond to a macromolecular carrier of polypeptide character, and also pharmaceutical compositions containing these conjugates and a process of preparation.

REFERENCES:
patent: 4675400 (1987-07-01), Cullinan
patent: 4828831 (1989-05-01), Hannart et al.
Brown et al. (1978), Arch. Biochem. Biophys., 188 (2):418-428.
Rao et al. (1985), in Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th volume, Anticancer Sect. 1, Ed. Ishiganni, Univ Tokyo Press, pp. 323-324.
Teale et al. (1977), Br. J. Clin. Pharmac., 4:169-172.

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