Conjugates in which a monovalent carboxylic ionophore is associa

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin

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530300, 530345, 530370, 5303911, 5303919, 530402, 530403, 530404, 530405, 530406, 530399, 530408, 530409, 530410, 424 8591, 424 858, 514 8, 514 12, C07K 1702, C07K 1514, A61K 3944

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active

051440091

ABSTRACT:
The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. It also relates to the activated inophores.
These conjugates are suitable as immunotoxin potentiators.

REFERENCES:
patent: 4767621 (1988-08-01), Jansen et al.
patent: 4919928 (1990-04-01), Jansen et al.
The Merck Index, product No. 6081, p. 810 Ninth edition, 1976 Merck & Co., Inc. Rahway, NJ.

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