Conjugates in which a monovalent carboxylic ionophore is associa

Details Conjugates in which a monovalent carboxylic ionophore is associa Conjugates in which a monovalent carboxylic ionophore is associa

1989-12-27

1990-12-11

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49310

Patent

active

049772805

ABSTRACT:
The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. It also relates to the activated ionophores.
These conjugates are suitable as immunotoxin potentiators.

REFERENCES:
patent: 3832358 (1974-08-01), Chamberlin
patent: 4431665 (1984-02-01), Kluge et al.
patent: 4542027 (1985-09-01), Clark

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