Conjugates in which a monovalent carboxylic ionophore is associa

Details Conjugates in which a monovalent carboxylic ionophore is associa Conjugates in which a monovalent carboxylic ionophore is associa

1987-04-06

1990-04-24

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 530389, 530390, 530391, 530402, 530403, 530404, 530405, 530406, 530408, 530409, 530410, 530370, 514885, 514 2, 514 8, 514 12, A61K 39395, A61K 3939, A61K 3700

Patent

active

049199285

ABSTRACT:
The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, and peptide ligands. It also relates to the activated ionophores.
These conjugates are suitable as immunotoxin potentiators.

REFERENCES:
patent: 4340535 (1982-07-01), Joisin et al.
patent: 4582703 (1986-04-01), Jansen et al.
patent: 4767621 (1988-08-01), Jansen et al.
Ray et al., CA vol. 95, 1981, #36779m.
Ray et al., CA vol. 95, 1981, #75056t.
V. Tetta et al. Science 219, 1983, pp. 644-650.

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